[Section 2.08(c)] is amended in full to read as follows:

[Section 2.1(g)] “Company” is hereby amended to read in full as follows:

[Section 2.1(p)] “Employer” is amended to read in full as follows:

[Section 2.1(s)] “Investment Indexes” is hereby amended to read in full as follows:

[Section 2.07(c)] is amended by replacing the table set forth therein in its entirety to read as follows:

[Section 2.12] is revised to read as follows:

[Section 2.2] of the Purchase Agreement shall be deleted and replaced with the following paragraphs:

[Section 2.11(a)] shall be amended and restated to read in its entirety as follows:

[Section 2.16] (Increase in Commitments) of the Credit Agreement is hereby amended by replacing the lead in phrase “At any time prior to the Business Day immediately preceding the Maturity Date…” with the phrase “At any time after the Amendment No. 1 Effective Date but prior to the Business Day immediately preceding the Maturity Date….”

[Section 2.9.5] shall apply upon In Vivo Proof-of-Concept (as defined in [Section 2.9.5]) being achieved for a [Schedule 1.93] Target.